After more than four decades of a failed war on drugs, calls for a change in strategy are growing louder by the day. In Latin America, the debate is positively deafening. Statesmen from Colombia, Guatemala, Mexico and Uruguay are taking the lead for transformations in their own drug regime, which has set a strong dynamic of change across the region and around the world. Their discussion has expanded to the US, where public opinion toward regulation is also changing. (See also: Western leaders study 'gamechanging' report on global drugs trade)